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By: M. Tragak, MD
Associate Professor, University of South Alabama College of Medicine
Two-lung ventilation should be instituted for the original laryngoscopy was difcult (above) treatment 7th feb bournemouth proven pepcid 20 mg. If possible symptoms nervous breakdown order pepcid online from canada, pulmonary Patients are observed in the postanesthesia care artery clamp can also be placed during unit medications 377 discount pepcid american express, and, in most instances, at least overnight or pneumonectomy to eliminate shunt. Postoperative hypoxemia and respiratory aci- disease, one should always be suspicious of dosis are common. Tese efects are largely caused pneumothorax on the dependent, ventilated by atelectasis and “shallow breathing (‘splinting’)” side as a cause of severe hypoxemia. Gravity-dependent transuda- complication requires immediate detection tion of fuid into the intraoperative dependent lung and treatment by aborting the surgical may also be contributory. Reexpansion edema of the procedure, reexpanding the operative lung, collapsed nondependent lung can also occur. Signs of hemorrhage Alternatives to One-Lung Ventilation include increased chest tube drainage (>200 mL/h), Ventilation can be stopped for short periods if 100% hypotension, tachycardia, and a falling hematocrit. Routine postoperative care should include ofen be maintained for prolonged periods, but pro- maintenance of a semiupright (>30°) position, gressive respiratory acidosis limits the use of this supplemental oxygen (40% to 50%), incentive spi- technique to 10–20 min in most patients. Arterial rometry, electrocardiographic and hemodynamic P co rises 6 mm Hg in the frst minute, followed by a monitoring, a postoperative chest radiograph (to 2 rise of 3–4 mm Hg during each subsequent minute. A standard tracheal tube may be Postoperative Analgesia used with either technique. Small tidal volumes The importance of adequate pain management in (<2 mL/kg) allow decreased lung excursion, which the thoracic surgical patient cannot be overstated. Irrespective of the modality used, there Postoperative Complications must be a comprehensive plan for pain management. Postoperative complications following thoracotomy A balance between comfort and respiratory are relatively common, but fortunately most are depression in patients with marginal lung function minor and resolve uneventfully. If parenteral opioids are used alone, they are lowing segmental or lobar resections. Terapeutic best administered via a patient-controlled analgesia bronchoscopy should be considered for persistent device. Air leaks from the operative hemitho- tal or paravertebral nerve blocks with long-acting rax are common following segmental and lobar local anesthetics may facilitate extubation, but have resections. Alternatively, large air leak from the chest tube that may be a cryoanalgesia probe may be used intraoperatively associated with an increasing pneumothorax and to freeze the intercostal nerves (cryoneurolysis) and partial lung collapse. When they occur within the produce long-lasting anesthesia; unfortunately, max- frst 24–72 hr, they are usually the result of inade- imum analgesia may not be achieved until 24–48 hr quate surgical closure of the bronchial stump. Nerve regen- Delayed presentation is usually due to necrosis of eration is reported to occur approximately 1 month the suture line associated with inadequate blood afer the cryoneurolysis. Torsion Epidural analgesia is the current optimal of a lobe or segment can occur as the remaining method for acute pain control following thoracic lung on the operative side expands to occupy the surgical procedures. The torsion usually occludes the pul- continuous therapy, and avoidance of the side efects monary vein to that part of the lung, causing venous associated with administration of systemic opioids. Hemoptysis and infarction can On the other hand, epidural techniques require rapidly follow. The diagnosis is suggested by an attention from the acute pain team for the duration enlarging homogeneous density on the chest radio- of the infusion and subject the patient to the long graph and a closed lobar orifce on bronchoscopy. However, there is still much debate over the tive hemithorax can occur through the peri- level of placement of the epidural catheter (tho- cardial defect that may remain following a racic versus lumbar), type of medication adminis- pneumonectomy. A large pressure diferential tered (opioid and/or local anesthetic), and timing between the two hemithoraces is thought to trigger of medication administration (before surgical inci- this catastrophic event. A given to awake, nonintubated, spontaneously ven- chest radiograph shows a shif of the cardiac shadow tilating patients because they are usually already into the operative hemithorax. If the patient is already intubated and has phrenic, vagus, and lef recurrent laryngeal nerves.
Patients with difuse bronchiec- “three-legged” stool of respiratory assessment tasis have a chronic obstructive ventilatory defect medicine holder generic pepcid 20 mg on-line. Preoperative Management Pulmonary infections may present as a solitary nod- ule or cavitary lesion (necrotizing pneumonitis) medicine 4 the people buy cheapest pepcid and pepcid. The majority of patients undergoing pulmonary An exploratory thoracotomy may be carried out resections have underlying lung disease medications you can take while breastfeeding safe 40 mg pepcid. It should to exclude malignancy and diagnose the infectious be emphasized that smoking is a risk factor for agent. Lung resection is also indicated for cavitary both chronic obstructive pulmonary disease and lesions that are refractory to antibiotic treatment, coronary artery disease; both disorders commonly are associated with refractory empyema, or result in coexist in patients presenting for thoracotomy. Tracheal or bronchial deviation can At least one large-bore (14- or 16-gauge) intrave- make tracheal intubation and proper positioning nous line is mandatory for all open thoracic surgi- of bronchial tubes much more difcult. Central venous access (preferably airway compression can lead to difculty in venti- on the side of the thoracotomy to avoid the risk of lating the patient following induction of anesthesia. The location sion device are also desirable if extensive blood loss of any bullous cysts or abscesses should be noted. Patients undergoing thoracic procedures are at increased risk of postoperative pulmonary and car- Monitoring diac complications. Perioperative arrhythmias, par- Direct monitoring of arterial pressure is indicated ticularly supraventricular tachycardias, are thought for resections of large tumors (particularly those to result from surgical manipulations or distention with mediastinal or chest wall extension), and any of the right atrium following reduction of the pul- procedure performed in patients who have limited monary vascular bed. The incidence of arrhythmias pulmonary reserve or signifcant cardiovascular increases with age and the amount of pulmonary disease. Intraoperative Management Less invasive measures of cardiac output through use of pulse contour analysis and transpulmo- Preparation nary thermodilution provide better estimates of As with anesthesia for cardiac surgery, optimal prep- cardiac function and volume responsiveness (See aration may help to prevent potentially catastrophic Chapter 5). A well thought-out plan to deal with disease or pulmonary hypertension, intraoperative potential difculties is necessary. Moreover, in addi- monitoring can be enhanced by the use of trans- tion to items for basic airway management, special- esophageal echocardiography. Tis may be of a potent halogenated agent (isofurane, sevofu- accomplished by incremental doses of the induction rane, or desfurane) and an opioid is preferred by agent, an opioid, or deepening the anesthesia with most clinicians. Advantages of the halogenated a volatile inhalation agent (the latter is particularly agents include: (1) potent dose-related bronchodila- useful in patients with reactive airways). Once the bron- efects on hypoxic pulmonary vasoconstriction (see choscopy is completed, the single-lumen tracheal below). Advantages of an opioid include: ventilation helps prevent atelectasis, paradoxical (1) generally minimal hemodynamic efects; breathing, and mediastinal shif; it also allows control (2) depression of airway refexes; and (3) residual of the operative feld to facilitate the surgery. If epidural opioids 3 are used postoperatively, intravenous opi- Positioning oids should be limited during surgery to prevent Following induction, intubation, and confrma- excessive postoperative respiratory depression. Proper positioning generally be restricted in patients undergoing pul- avoids injuries and facilitates surgical exposure. Excessive fuid administration in lower arm is fexed and the upper arm is extended in thoracic surgical patients has been associated with front of the head, pulling the scapula away from the acute lung injury in the postoperative period. Pillows are placed fuid replacement for estimated “third space” losses between the arms and legs, and an axillary (chest) should be administered during lung resection. Moreover, the collapsed way to treat hypoxemia that occurs immediately lung may be prone to acute lung injury due to surgi- afer the onset of one-lung ventilation. Patients cal retraction during the procedure and possible with obstructive pathology may develop intrinsic ischemia–reperfusion injury.
It dema medications that cause tinnitus discount 20mg pepcid with visa, mucus secretion and damage to the ciliated epithe- is important to recognise that asthma may coexist with lium treatment tmj discount 20mg pepcid mastercard. Breaching of the protective epithelial barrier allows chronic obstructive pulmonary disease medicine 48 12 buy pepcid 20mg line, and to assess their hyperreactivity to be maintained by bronchoconstrictor responses to bronchodilators or glucocorticoids over a pe- substances or by local axon reflexes through exposed nerve riod of time (as formal tests of respiratory function may not fibres. Apart from cough and bron- • Reduction of the bronchial inflammation and chospasm induced by the powder it may rarely cause aller- hyperreactivity. These objectives may be achieved as follows: Nedocromil sodium (Tilade) is structurally unrelated to cromoglicate but has a similar profile of actions and can be used by metered aerosol in place of cromoglicate. Ketotifen is a histamine H1-receptor blocker This approach is appropriate for extrinsic asthmatics. Identi- that may also have some anti-asthma effects but its benefit fication of an allergen may be aided by the patient’s history has not been demonstrated conclusively. In common with (wheezing in response to contact with grasses, pollens, ani- other antihistamines it causes drowsiness. Avoiding an allergen may be feasible when it is related This is achieved most effectively by physiological antagonism to some specific situation, e. Pharmacological antagonism of specific bronchoconstrictors is less effective, either because individual mediators are not on their own Reduction of the bronchial inflammation responsible for a large part of the bronchoconstriction (ace- and hyperreactivity tylcholine, adenosine, leukotrienes) or because the media- As persistent inflammation is central to bronchial hyper- tor is not even secreted during asthma attacks (histamine). The predominant adrenocep- tors in bronchi are of the b2 type and their stimulation Glucocorticoids (see p. The exact mechanisms are still disputed include salbutamol, terbutaline, fenoterol, eformoterol and but probably include: inhibition of the influx of inflamma- salmeterol, and are discussed in Chapter 23. Salmeterol is tory cells into the lung after allergen exposure; inhibition of longer acting because its lipophilic side-chain anchors the release of mediators from macrophages and eosino- the drug in the membrane adjacent to the receptor, slowing phils; and reduction of the microvascular leakage that these tissue washout. Glucocorticoids used in asthma include Less selective adrenoceptor agonists such as adrenaline/ prednisolone (orally), and beclometasone, fluticasone and epinephrine, ephedrine, isoetharine, isoprenaline and orci- budesonide (by inhalation) (see Ch. Evidence now suggests that the late allergic response and Theophylline, a methylxanthine, relaxes bronchial mus- bronchial hyperreactivity are also inhibited, and points cle, although its precise mode of action is still debated. Cromoglicate is poorly type 4 isoform, now seems the most likely explanation absorbed from the gastrointestinal tract but well absorbed for its bronchodilating and more recently reported anti- from the lung, and it is given by inhalation (as powder, inflammatory effects. Blockade of adenosine receptors is aerosol or nebuliser); it is eliminated unchanged in the probably unimportant. Special formulations are used for allergic rhinitis and lised by the liver and there is evidence that the process is allergic conjunctivitis. It is prolonged in patients with severe mostly in older patients with chronic obstructive pulmo- cardiopulmonary disease and cirrhosis; obesity and prema- nary disease, but are useful in acute severe asthma when turity are associated with reduced rates of elimination; combined with b2-adrenoceptor agonists. Vagally medi- tobacco smoking enhances theophylline clearance by ated bronchoconstriction appears to be important in acute inducing hepatic P450 enzymes. These pharmacokinetic asthma, but relatively unimportant for most chronic stable factors and the low therapeutic index render necessary asthmatics. They have similar efficacy either as a salt with choline (choline theophyllinate) or to low-dose inhaled glucocorticoid. Aminophylline parisons with established medications consigns them to a is sufficiently soluble to permit intravenous use of the- second- or third-line role in treatment. There are no studies to (below) by exposing the heart and brain to high concentra- justify their use as steroid-sparing (far less, replacement) tions before distribution is complete.
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