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This concept is now applied in cardiac arrhythmias with defined anatomic pathways—eg medications you can take while breastfeeding order aricept 5 mg without a prescription, atrioventricular reentry using accessory pathways symptoms 3 days dpo purchase aricept on line amex, atrioventricular node reentry symptoms parkinsons disease best order for aricept, atrial flutter, and some forms of ventricular tachycardia—by treatment with radiofrequency catheter ablation or extreme cold, cryoablation. Mapping of reentrant pathways and ablation can be carried out by means of catheters threaded into the heart from peripheral arteries and veins. Recent studies have shown that paroxysmal and persistent atrial fibrillation may arise from one or more of the pulmonary veins. Both forms of atrial fibrillation can be cured by electrically isolating the pulmonary veins by radiofrequency catheter ablation or during concomitant cardiac surgery. The increasing use of nonpharmacologic antiarrhythmic therapies reflects both advances in the relevant technologies and an increasing appreciation of the dangers of long- term therapy with currently available drugs. Toxicity Adenosine causes flushing in about 20% of patients and shortness of breath or chest burning (perhaps related to bronchospasm) in over 10%. Unlike other heart rate-lowering agents such as β blockers, it reduces heart rate without affecting myocardial contractility, ventricular repolarization, or intracardiac conduction. Elevated heart rate is an important determinant of the ischemic threshold in patients with coronary artery disease and a prognostic indicator in patients with congestive heart failure. Antianginal and anti-ischemic effects of ivabradine have been demonstrated in patients with coronary artery disease and chronic stable angina. In patients with left ventricular dysfunction and heart rates greater than 70 bpm, ivabradine reduced mean heart rate and the composite end points of cardiovascular mortality and hospitalization. Inappropriate sinus tachycardia is an uncommon disorder characterized by multiple symptoms, including palpitations, dizziness, orthostatic intolerance, and elevated heart rates. Recent case reports and one clinical trial have shown that ivabradine provides an effective alternative to slow the heart rate in patients with inappropriate sinus tachycardia. Subsequent studies have demonstrated antiarrhythmic properties that are dependent on the blockade of multiple ion channels. Ranolazine had been shown to have antiarrhythmic properties in both atrial and ventricular arrhythmias. It is currently undergoing clinical trials in combination with dronedarone for the suppression of atrial fibrillation. Ranolazine has been shown to suppress ventricular tachycardia in ischemic models and in a major clinical trial of its effects in coronary artery disease. Magnesium therapy appears to be indicated in patients with digitalis-induced arrhythmias if hypomagnesemia is present; it is also indicated in some patients with torsades de pointes even if serum magnesium is normal. The usual dosage is 1 g (as sulfate) given intravenously over 20 minutes and repeated once if necessary. A full understanding of the action and indications for the use of magnesium as an antiarrhythmic drug awaits further investigation. The effects of increasing serum K can be summarized as (1) a resting potential depolarizing action and (2) a membrane potential stabilizing action, the latter caused by increased potassium permeability. Hypokalemia results in an increased risk of early and delayed afterdepolarizations, and ectopic pacemaker activity, especially in the presence of digitalis. Because both insufficient and excess potassium is potentially arrhythmogenic, potassium therapy is directed toward normalizing potassium gradients and pools in the body. However, the chloride channels involved in cystic fibrosis and other conditions are of great clinical importance and have been the subject of intensive research (see Box: A Cystic Fibrosis Link in the Heart? Risks and benefits must be carefully considered (see Box: Antiarrhythmic Drug-Use Principles Applied to Atrial Fibrillation).

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The lateral meniscus (A9) is not attached to the fbular (lateral) collateral ligament (A6) medicine 94 order cheap aricept on line, but is attached posteriorly to the popliteus muscle treatment trichomonas generic 10mg aricept with amex. The tibial collateral (medial) ligament is a broad fat band about 12 cm long medicine 223 generic 5 mg aricept amex, passing from the medial epicondyle of the femur to the medial condyle of the tibia and an extensive area of the medial surface of the tibia below the condyle. The anterior cruciate ligament (A1) passes upwards, backwards and laterally to be attached to the medial side of the lateral condyle of the femur (C7). The posterior cruciate ligament (C14) passes upwards, forwards and medially to be attached to the lateral surface of the medial condyle of the femur (A10). A 1 N T 5 13 E R B 21 1 17 I O 2 7 R 15 8 6 10 9 3 14 21 4 10 7 19 7 12 6 12 20 18 16 1 Anterior cruciate ligament 8 Patella 15 Semimembranosus 2 Femur 9 Patellar apex 16 Soleus 3 Infrapatellar fat pad (Hoffa) 10 Patellar ligament (tendon) 17 Tendon of quadriceps 4 Intercondylar notch 11 Popliteal artery and vein 18 Tibia 5 Lateral condyle of femur 12 Popliteus 19 Tibial (medial) collateral ligament 6 Lateral head of gastrocnemius muscle 13 Posterior cruciate ligament 20 Tibial tubercle 7 Lateral meniscus 14 Posterior meniscofemoral ligament 21 Transverse (intermeniscal) ligament Left knee arthroscopic views C anterolateral approach C D 1 7 posteromedial approach D 1 Lateral condyle of femur 5 Medial meniscus 4 2 Lateral condyle of tibia 6 Posterior cruciate ligament 3 3 Lateral meniscus 7 Posterior part of capsule 4 Medial condyle of femur 2 6 5 Rupture–posterior cruciate ligament, suprapatellar bursitis, see pages 355–357. Knee 335 E Left knee joint E 5 5 opened from the lateral side to reveal internal 16 structures 17 1 Anterior cruciate ligament 2 2 Aponeurosis of vastus lateralis (cut edge) 3 Articular cartilage, tibial plateau 18 4 Deep infrapatellar bursa 5 Fascia lata (deep fascia) 6 Fibular collateral ligament 11 12 7 Head of fbula 8 8 Iliotibial tract (cut edge) 9 Infrapatellar fat pad (Hoffa) 10 Lateral meniscus 11 Patella 12 Patellar articular cartilage 13 Patellar ligament (tendon) 8 14 Popliteus tendon, attachment to lateral tibial 13 epicondyle 9 15 Posterior cruciate ligament 16 Quadriceps tendon 15 17 Suprapatellar bursa 4 18 Suprapatellar fat pad 1 19 Tibial tuberosity 14 10 6 3 F Left knee joint from the medial side, 19 with synovial and bursal cavities injected 7 The resin injection has distended the synovial cavity of the joint (3) and extends into the suprapatellar bursa (10), the bursa round the popliteus tendon (2) and the semimembranosus bursa (9). The regular space between the condyles of the femur and tibia (7 and 8, 11 and 12) is due to the thickness of the hyaline cartilage on the articulating surface, with the menisci at the periphery. In C, with the knee fexed, the view should be compared with the bones seen on page 299, E, and the lateral edge of the patella (9) is seen in the arthroscopic view in E. Leg 337 A Left leg from the front and lateral side 1 Anterior tibial artery overlying 8 Medial branch of superfcial peroneal interosseous membrane (fbular) nerve 2 Branch of deep peroneal (fbular) nerve 9 Peroneus (fbularis) longus to tibialis anterior 10 Recurrent branch of common peroneal 3 Deep peroneal (fbular) nerve (fbular) nerve 4 Extensor digitorum longus 11 Superfcial peroneal (fbular) nerve 5 Extensor hallucis longus 12 Tibialis anterior and overlying fascia 6 Head of fbula 13 Tuberosity of tibia and patellar ligament 7 Lateral branch of superfcial peroneal 6 (fbular) nerve 13 4 9 10 3 2 B Left knee from the lateral side to show 11 common peroneal (fbular) nerve and articular branches 12 1 4 9 2 12 1 5 11 13 3 4 12 4 9 6 15 7 2 8 5 6 14 16 16 8 7 9 9 10 10 1 Anterior ligament of fbular head 9 Extensor digitorum longus 2 Anterior tibial recurrent artery and vein 10 Peroneus (fbularis) longus 3 Articular branch from deep common peroneal (fbular) nerve 11 Head of fbula 4 Articular vessels 12 Iliotibial tract 5 Biceps femoris tendon 13 Interosseous membrane 6 Common peroneal (fbular) nerve, deep branches 14 Lateral head, gastrocnemius muscle 7 Common peroneal (fbular) nerve, overlying neck of fbula 15 Recurrent branch of deep peroneal (fbular) nerve 8 Common peroneal (fbular) nerve, superfcial branch 16 Tibialis anterior Common peroneal (fbular) nerve paralysis, see pages 355–357. The common joint to show part of the medial condyle of the femur (7) peroneal (fbular) nerve (2) runs down behind biceps and the medial meniscus (1). The superfcial 2 Branches of superior medial genicular artery peroneal (fbular) nerve becomes superfcial between 3 Gracilis peroneus (fbularis) longus (13) and extensor digitorum 4 Great saphenous vein longus (3). In the calf, the small saphenous vein (C7) is accompanied by superfcial dissection, from behind the sural nerve (C9). The 2 commonest sites for them are just behind the tibia, behind the fbula and in the adductor B canal. These communicating A 7 vessels possess valves which C 5 direct the blood fow from K 4 superfcial to deep; venous return from the limb is then 6 brought about by the pumping M action of the deep muscles (which are all below the deep E fascia). If the valves become D incompetent or the deep veins 6 I blocked, pressure in the 10 7 A superfcial veins increases and 9 L they become varicose (dilated 8 6 and tortuous) (see page 357). Leg 343 C Right lower leg D Popliteal angiogram deep dissection 1 Anterior tibial artery 2 Inferior lateral genicular artery 4 4 3 Inferior medial genicular artery 7 4 Muscular branches of 13 9 anterior tibial 11 artery 10 10 5 Muscular branches of 5 tibioperoneal 7 trunk 14 6 Peroneal (fbular) artery 10 7 Popliteal artery 1 8 Tibioperoneal trunk 2 9 Superior lateral 3 genicular artery 10 Superior medial genicular artery 11 Posterior tibial artery 2 6 9 13 4 8 1 3 5 6 11 8 12 1 Fibula (posterior surface) 8 Plantaris tendon 2 Flexor digitorum longus 9 Posterior tibial artery muscle 10 Popliteus muscle 3 Flexor hallucis longus muscle 11 Soleus muscle 4 Gastrocnemius muscle 12 Tendocalcaneus (Achilles) 5 Peroneal (fbular) artery 13 Tibial nerve 6 Peroneus (fbularis) longus 14 Tibia, posterior surface 7 Plantaris muscle 344 Ankle and foot A Right ankle and foot from the lateral side 1 Extensor digitorum brevis 2 Lateral malleolus 3 Peroneus (fbularis) longus and brevis 3 4 Small saphenous vein 5 Tendocalcaneus (Achilles tendon) 6 Tibialis anterior 7 Tuberosity of base of ffth metatarsal 5 2 The great saphenous vein (B7) runs upwards in front of the medial malleolus (B9). Ankle and foot 345 10 C Right ankle and foot from the lateral side 20 Fascia has been removed but the thickenings that form the superior and inferior extensor 4 retinacula (16 and 6) and the superior and inferior peroneal (fbular) retinacula (17 and 7) 11 have been preserved. The great saphenous vein (3) runs upwards 4 Flexor hallucis longus in front of the medial malleolus (4) with the posterior arch 5 Flexor retinaculum vein (5) behind it. Ankle and foot 347 C Left ankle and foot C 14 11 from the front and lateral side 3 10 13 The foot is plantar fexed and part of the capsule of the ankle joint has been removed to show the talus (1). The tendons of peroneus (fbularis) tertius (12) and extensor digitorum longus (5) lie superfcial to extensor digitorum 17 6 16 brevis (4). The talus (18) is in the centre, with the medial malleolus 15 18 9 (9) on the left of the picture and the lateral malleolus (8) on the right. The small 7 21 saphenous vein (16) and the sural 4 nerve (17) are behind the lateral malleolus, with the tendons of peroneus (fbularis) longus (11) and peroneus (fbularis) brevis (10) 1 Deep peroneal (fbular) nerve 12 Peroneus (fbularis) tertius intervening. At the front of the 2 Dorsalis pedis artery and venae comitantes 13 Posterior talofbular ligament ankle, the dorsalis pedis vessels (2) 3 Extensor digitorum longus 14 Posterior tibial artery and venae comitantes and deep peroneal (fbular) nerve 4 Extensor hallucis longus 15 Saphenous nerve 5 Flexor digitorum longus 16 Small saphenous vein (1) are between the tendons of 6 Flexor hallucis longus 17 Sural nerve extensor hallucis longus (4) and 7 Great saphenous vein 18 Talus extensor digitorum longus (3). Ankle and foot 349 Left ankle and foot ligaments 1 Anterior talofbular ligament 15 C from the medial side 2 Calcaneocuboid part of bifurcate C ligament D from the lateral side 3 Calcaneofbular ligament 4 Calcaneonavicular part of bifurcate ligament E from behind 5 Cervical ligament B 6 A 6 Deltoid ligament In C, the marker below the medial 7 Groove below sustentaculum tali for C 10 malleolus (15) passes between the fexor hallucis longus K 26 superfcial and deep parts of the 8 Groove on lateral malleolus for deltoid ligament (6). The marker peroneus (fbularis) brevis 7 18 below the tuberosity of the 9 Groove on medial malleolus for tibialis navicular (26) passes between the posterior 17 10 Groove on talus for fexor hallucis plantar calcaneonavicular (spring) longus and calcaneocuboid (short plantar) 11 Groove on tibia for fexor hallucis 14 ligaments (18 and 17). Foot 351 Sole of the left foot C after removal of fexor digitorum brevis D after removal of fexor digitorum longus C D 17 5 18 5 5 5 11 18 4 11 17 7 10 12 10 7 3 20 12 20 9 16 16 1 1 Abductor digiti minimi 15 11 2 Abductor hallucis 19 3 Adductor hallucis, oblique head 4 Adductor hallucis, 14 transverse head 13 9 14 5 Fibrous sheath, fexors 19 6 Flexor accessorius 6 (quadratus plantae) 6 2 7 Flexor digiti minimi 1 13 brevis 8 Flexor digitorum brevis (cut) 8 9 Flexor digitorum 2 8 longus 10 Flexor hallucis brevis 11 Flexor hallucis longus 12 Interossei 13 Lateral plantar artery 14 Lateral plantar nerve 15 Lateral plantar nerve, common digital branch 16 Lateral plantar nerve, deep branch 17 Lumbrical 18 Medial plantar artery 19 Medial plantar nerve 20 Medial plantar nerve, common digital branch Extensor plantar response–Babinski sign, see pages 355–357.

She reports that Mary Jane Smith is a 72-year-old woman who is referred by her she is sleeping much better now that she is taking zolpidem medications known to cause hair loss purchase aricept without a prescription. She has a primary care physician to a Pharmacotherapy Clinic for medication long history of depression and was hospitalized for depression therapy management for diabetes symptoms 0f pneumonia order aricept with paypal. She is accompanied by her daughter who gives most of the uses incontinence briefs and reports urinary frequency and urgency symptoms meningitis buy aricept with amex. The patient states that she has had difficulty sleeping She has a longstanding history of losing urine when she coughs or 197 sneezes. Which information (signs, symptoms, laboratory values) indi- Lungs cates the presence or severity of insomnia? No C/C/E; normal muscle bulk and tone; muscle strength 5/5 and equal in all extremities; 1+ popliteal and dorsalis pedis pulses; 3. What feasible pharmacotherapeutic alternatives are available decreased lower extremity sensation to monofilament bilaterally; for treatment of insomnia? What information should be provided to the patient to enhance adherence, ensure successful therapy, and minimize adverse A1C 9. For questions related to the use of valerian for insomnia, please potentially inappropriate medication use in older adults. She states that 78 she has been under a “lot of stress” in the last 2 months preparing for her wedding and graduation. Her roommate suggested she call her doctor, but Buffy believed the antibiotic could be the cause of her stomach upset leading to her hyperglycemia. She vomited five more times that After completing this case study, the reader should be able to: evening before falling asleep for several hours. The paramedics noted coffee ground emesis in the toilet, Kussmaul respirations (and timed it to be 30 breaths/min), and “fruity breath. She was very warm to the touch, and they noted • Identify anticipated electrolyte abnormalities associated with the large lesion on her left foot. She has no paresthe- lin therapy and calculate the dose of insulin that should be sias of the feet or hands and has never previously had a foot ulcer. Her mother suspects Buffy has not been taking insulin • Provide education on lifestyle modifications to help control regularly and is concerned about her recent weight loss. I think I have an infected blister on my foot the past 5 years that is causing all of this” this morning just hours before she vomited and collapsed in the bathroom of their dormitory. She and her mom returned 2 days ago from a 5-day Mother, age 43, has Type 2 diabetes and hypertension vacation in Key West, and she returned to her college dormitory One sister, age 15 and healthy Copyright © 2009 by the McGraw-Hill Companies, Inc. Diabetic ketoacidosis precipitated by foot ulcer, stress, and de- creased insulin adherence Unremarkable 2. Are there any other medications that should be added to her regimen based on her presenting laboratory values and/or history of present illness? Describe the doses and outcomes for the use of rapid acting and identify factors to enhance patient adherence. Persons with diabetes are at risk for developing cardiovascular í Chief Complaint disease and end-stage renal disease. Describe therapeutic approaches “My gynecologist said I should have a check-up since I am tired all to prevent these two complications.

Diseases

It is attached Infratemporal crest Foramen ovale Foramen spinosum Petrotympanic fissure Pterygomaxillary fissure (leading into pterygopalatine fossa) Tensor veli palatini Aiveolar foramen Levator veli palatini Posterior surface of maxilla Pharynx Pterygomandibular raphe Mylohyoid Hyoglossus Fig symptoms rabies purchase aricept overnight delivery. Infratemporal crest Foramen ovale Foramen spinosum Petrotympanic fissure Tensor veli palatini Levator veli palatini Deep head medial pterygoid Supericial head medial pterygoid ligament canal Lingula Fig symptoms inner ear infection cheap aricept 5mg with visa. When the pterygoid process symptoms multiple sclerosis buy generic aricept on-line, and the inferior part insinuates opposite movements at the two temporomandibular joints itself between the cranial attachments of the two heads are coordinated, a chewing movement results. Mandibular nerve [V3] The fbers from both heads of the lateral pterygoid The mandibular nerve [V3] is the largest of the three divi­ muscle converge to insert into the pterygoid fovea of the sions of the trigeminal nerve [V]. Infratemporal crest Upper head of lateral pterygoid Articular disc Lower head lateral pterygoid Superficial head medial pterygoid ligament Deep head medial pterygoid Fig. Like the ophthalmic [V1] and maxillary [V2] nerves, • Branches from theposterior trunk arethe auriculotem­ the sensory part of the mandibular nerve [V3] originates poral, lingual, and inferior alveolar nerves, all of which, from the trigeminal ganglion in the middle cranial fossa except a small nerve (nerve to the mylohyoid) that (Fig. It is sensory for the dura mater, mainly of the then passes through the foramen ovale and immediately middle cranial fossa, and also supplies the mastoid cells joins the sensory part of the mandibular nerve [V3]. Upper head Anterior trunk lateral pterygoid (cut) Meningeal branch Nerve to lateral pterygoid Branch to tensor tympani Buccal nerve Branch to tensor veli palatini Nerve to medial pterygoid Deep head medial pterygoid head lateral pterygoid (cut) Fig. Near its origin from the mandibular nerve [V3], it through the mandibular notch to penetrate and supply the has two small branches: masseter muscle. Deep temporal nerves • The other ascends to supply the tensor tympani muscle, The deep temporal nerves, usually two in number, origi­ which occupies a smallbony canal above and parallel to nate from the anterior trunk of the mandibular nerve [V3] the pharyngotympanic tube in the temporal bone. They pass laterally above the lateral pterygoid muscle and curve around the infra­ temporal crest to ascend in the temporal fossa and supply Buccal nerve the temporalis muscle from its deep surface. It is predominantly a Nerve to lateral pterygoid sensory nerve, but may also carry the motor innervation Thenerve to the lateral pterygoid may originate directly as to the lateral pterygoid muscle and to part of the temporalis a branch from the anterior trunk of themandibular nerve muscle. From its origin, The buccal nerve passes laterally between the upper it passes directly into the deep surface of the lateral ptery­ and lower heads of the lateral pterygoid and then descends goid muscle. It continues into the cheek lateral to the buccina­ teriortrunk of the mandibular nerve [V3] and originates as tor muscle to supply general sensory nerves to the adjacent two roots, which pass posteriorly around the middle men­ skin and oral mucosa and the buccal gingivae of the lower ingeal artery ascending from the maxillary artery to the molars. The auriculotemporal nerve passes frst between the the tongue, oral mucosa on the floor of the oral cavity, and tensor veli palatini muscle and the upper head of the lateral lingual gingivae associated with the lower teeth. In addition, the auriculotemporal nerve con­ tributes to sensory innervation of the external ear, the The lingual nerve frst descends between the tensor veli external auditory meatus, tympanic membrane, and tem­ palatini muscle and the lateral pterygoid muscle, where it poromandibular joint. The lingual nerve enters the oral cavity between the Lingual nerve posterior attachment of the mylohyoid muscle to the The lingual nerve is a major sensory branch of the pos- mylohyoid line and the attachment of the superior con­ 986 teriortrunk of the mandibular nerve [V3] (Fig. Itcarries general sensation from the anterior two-thirds of As the lingual nerve enters the floor of the oral cavity, Regional anatomy • Temporal and Infratemporal Fossae Chorda tympani and the lesser petrosal nerve it is in a shallow groove on the medial surface of the mandible immediately inferior to the last molar tooth. Branches of two cranial nerves join branches of the man­ In this position, it is palpable through the oral mucosa dibular nerve [V3] in the infratemporal fossa (Fig. In addition to mastoid wall of the middle ear, passes anteriorly through innervating all lower teeth and much of the associated a small canal, and enters the lateral aspect of the middle gingivae, it also supplies the mucosa and skin of the lower ear. It has one motor branch, which it is separated from the tympanic membrane by the handle innervates the mylohyoid muscle and the anterior belly of of the malleus. It descends on the lateral surface of the medial chorda tympani synapse with postganglionic parasympa­ pterygoid muscle, passes between the sphenomandibular thetic fbers in the submandibular ganglion, which "hangs ligament and the ramus of the mandible, and then enters off" the lingual nerve in the floor of the oral cavity (Fig. Just before entering the mandibular foramen, it gives Postganglionic parasympathetic fbers leave the sub­ origin to the nerve to the mylohyoid (Fig. The inferior alveolar nerve supplies branches to the three molar teeth and the second premolar tooth and asso­ In the clinic ciated labial gingivae, and then divides into its two termi­ Lingual nerve injury nal branches: A lingual nerve injury proximal to where the chorda tympanijoins it in the infratemporal fossa will produce • the incisive nerve, which continues inthe mandibular loss of general sensation from the anterior two-thirds of canal to supply the frst premolar, incisor, and canine the tongue, oral mucosa, gingivae, the lower lip, and teeth, and related gingivae; and the chin. The mental nerve is palpable and salivary glands below the oral fssure and taste from the sometimes visible through the oral mucosa adjacent to anterior two-thirds ofthe tongue will also be lost.

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